The Aula Isiaca, brought to light in 1912 below the Basilica of the Domus Flavia, was part of the great residence of Augustus. The apsed chamber is richly frescoed with paintings, dating from around 30 BCE, presenting numerous references to Egypt and the goddess Isis, such as lotus flowers, snakes, ritual vases and garlands of roses, hence its current name.
The Loggia Mattei was frescoed in the 1520s by the workshop of Baldassarre Peruzzi, and is all that remains of the villa built by the Stati family. It then passed in 1561 into the possession of the Mattei. The vault, decorated with grotesques, is framed by a yellow frieze with masks, within which appear the Mattei coat of arms and two panels on mythological themes: the Marriage of Hercules and Hebe and Venus between Love and the Muses. The webs in the vault are decorated with tondi with a blue ground and the signs of the zodiac. The frescoes on the walls, with scenes from the myth of Venus and Adonis, were detached in 1846 and moved to the Hermitage Museum, where they are still kept today. A few years later the mythological representations and the tondi with the zodiacal signs were also detached and sold to the Metropolitan Museum of Art in New York. A loan agreement in the 1990s has allowed them to be reinserted in the original site.